The untapped potential of Fexofenadine
Our target portfolio is focused on exploring the untapped potential of Fexofenadine (FX). It comprises six drug concepts potentially covering up to 12 indications. FX has a high therapeutic index and a safety profile close to placebo even at doses up to four times the prescribed. The antihistamine (H1R antagonist) property of FX is well documented, and we are currently exploring how it can be leveraged in a dose-response dependent way in diseases characterized by itching (pruritus).
Our FX drug concepts also explore how the recently identified anti-inflammatory properties of FX can be manifested in clinical practice. FX has been described to reduce the levels of TNF-α by blocking the cPLA2 pathway. A proposed model for this property was presented in 2019. We suggest that the cPLA2 blocking ability of FX is an untapped resource that is likely to be dose-response dependent and manifested by means of DRPx strategies to achieve high focal concentrations in proximity to the pathological process.
With the high tolerability of FX our drug concepts are well suited for targeting unmet medical needs in sensitive patient groups, such as children, the elderly, and renally or hepatically impaired. The exploration of Fexofenadine as an untapped resource in clinical practice is just the start of our passion for DRPx innovation.
Our FX drug concepts also explore how the recently identified anti-inflammatory properties of FX can be manifested in clinical practice. FX has been described to reduce the levels of TNF-α by blocking the cPLA2 pathway. A proposed model for this property was presented in 2019. We suggest that the cPLA2 blocking ability of FX is an untapped resource that is likely to be dose-response dependent and manifested by means of DRPx strategies to achieve high focal concentrations in proximity to the pathological process.
With the high tolerability of FX our drug concepts are well suited for targeting unmet medical needs in sensitive patient groups, such as children, the elderly, and renally or hepatically impaired. The exploration of Fexofenadine as an untapped resource in clinical practice is just the start of our passion for DRPx innovation.